Mechanisms of vascularization in murine models of primary and metastatic tumor growth
Edina Bugyik, Ferenc Renyi-Vamos, Vanessza Szabo, Katalin Dezso, Nora Ecker, Andras Rokusz, Peter Nagy, Balazs Dome and Sandor Paku
1st Department of Pathology and Experimental Cancer Research, Semmelweis University
[Abstract] Directed capillary ingrowth has long been considered synonymous with tumor vascularization. However, the vasculature of primary tumors and metastases is not necessarily formed by endothelial cell sprouting; instead, malignant tumors can acquire blood vessels via alternative vascularization mechanisms, such as intussusceptive microvascular growth, vessel co-option, and glomeruloid angiogenesis. Importantly, in response to anti-angiogenic therapies, malignant tumors can switch from one vascularization mechanism to another. In this article, we briefly review the biological features of these mechanisms and discuss on their significance in medical oncology.
Chinese Journal of Cancer
2016, Volume: 35, Issue 2