Cancer Communications
indexed by SCI
BMC

doi: 10.1186/s40880-017-0246-z
The prognostic value of C-X-C motif chemokine receptor 4 in patients with sporadic malignant peripheral nerve sheath tumors
Chao Zhang, Fang-Yuan Chang, Wen-Ya Zhou and Ji-Long Yang
Department of Bone and Soft Tissue Tumor, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital; Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital
[Abstract]

Background
Recent studies indicate that C-X-C motif chemokine receptor 4 (CXCR4) and its ligand, C-X-C motif chemokine ligand 12 (CXCL12), stimulate expression of the cell cycle regulatory protein Cyclin D1 in neurofibromatosis 1-associated malignant peripheral nerve sheath tumor (MPNST) cells and promote their proliferation. In this study, we measured the expression of CXCR4, CXCL12, and Cyclin D1 proteins in sporadic MPNST tissues from Chinese patients and investigated their prognostic values.
Methods
CXCR4, CXCL12, and Cyclin D1 protein expression in samples from 58 Chinese patients with sporadic MPNST was assessed with immunohistochemical staining. Their prognostic values were evaluated with Kaplan–Meier analysis and a log-rank test. Multivariate Cox regression analysis was used to identify independent prognostic factors.
Results
High expression of CXCR4, CXCL12, and Cyclin D1 was observed in 19 (32.8%), 32 (55.2%), and 16 (27.6%) samples, respectively. CXCR4 expression was positively correlated with CXCL12 expression (r = 0.334, P = 0.010) and Cyclin D1 expression (r = 0.309, P = 0.018). Patients with high CXCR4 expression showed longer overall survival than those with low CXCR4 expression (χ2 = 4.642, P = 0.031).
Conclusion
High CXCR4 expression may define a specific subtype of sporadic MPNST with favorable prognosis.
Chinese Journal of Cancer 2017, Volume: 36, Issue 11
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Chao Zhang, Fang-Yuan Chang, Wen-Ya Zhou and Ji-Long Yang. The prognostic value of C-X-C motif chemokine receptor 4 in patients with sporadic malignant peripheral nerve sheath tumors. Chin J Cancer. 2017, 36:80. doi:10.1186/s40880-017-0246-z


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