Cancer Communications
indexed by SCI
BMC

doi: 10.1186/s40880-017-0181-z
Arresting kinase suppressor of Ras in an inactive state
Syed Lal Badshah and Yahia Mabkhot
Department of Chemistry, Islamia College University Peshawar
[Abstract] Ras protein signaling pathways are important in controlling the plight of different types of cancer. Here we discussed the paper entitled “Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling” published in Nature journal on inactivating the kinase suppressor of Ras (KSR) protein using a small molecule as an inhibitor by Dhawan et al. A biphenyl ether analogue of a quinazoline binds in one of the binding pockets of KSR and results in stabilization of its inactive state. In this inactive state, KSR is unable to take part in the cascade of protein association to perform the signalling process.
Chinese Journal of Cancer 2017, Volume: 36, Issue 1
[ PDF Full-text ]
[ Html full-text / Citation export] (BioMed Central)

[Google Scholar]


Cite this article

Syed Lal Badshah and Yahia Mabkhot. Arresting kinase suppressor of Ras in an inactive state. Chin J Cancer. 2017, 36:5. doi:10.1186/s40880-017-0181-z


Export citations

EndNote


SHARE THIS ARTICLE


Your Comments

  

 


Comments:


CC Wechat 微信公众号

 

Editorial Manager


CC adopts Editorial Manager to manage its submissions from Dec.18, 2014
 

 

Reference style for  

 EndNote,
 Reference Manager



Editorial Manager


 

Year:

 

Month:

Advanced search

Subscription


CJC is now published by BioMed Central

© Chinese Journal of Cancer

Sun Yat-sen University Cancer Center

651 Dongfeng Road East, Guangzhou 510060, P. R. China