doi: 10.1186/s40880-015-0052-4

Wnt3a: functions and implications in cancer

Sha He, Yi Lu, Xia Liu, Xin Huang, Evan T. Keller, Chao-Nan Qian and Jian Zhang

Key Laboratory of Longevity and Ageing-related Diseases, Ministry of Education, Nanning 530021, Guangxi, P.R. China

[Abstract] Wnt3a, one of Wnt family members, plays key roles in regulating pleiotropic cellular functions, including self-renewal, proliferation, differentiation, and motility. Accumulating evidence has suggested that Wnt3a promotes or suppresses tumor progression via the canonical Wnt signaling pathway depending on cancer type. In addition, the roles of Wnt3a signaling can be inhibited by multiple proteins or chemicals. Herein, we summarize the latest findings on Wnt3a as an important therapeutic target in cancer.

Chinese Journal of Cancer 2015, Volume: 34, Issue 12

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Sha He, Yi Lu, Xia Liu, Xin Huang, Evan T. Keller, Chao-Nan Qian and Jian Zhang. Wnt3a: functions and implications in cancer. Chin J Cancer. 2015, 34:50. doi:10.1186/s40880-015-0052-4


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