[ Special series on Hepatocellular Carcinoma ]
doi: 10.1186/s40880-015-0014-x
Hepatocellular adenoma with malignant transformation in male patients with non-cirrhotic livers
Song-Lin An, Li-Ming Wang, Wei-Qi Rong, Fan Wu, Wei Sun, Wei-Bo Yu, Li Feng, Fa-Qiang Liu, Fei Tian and Jian-Xiong Wu
Department of Abdominal Surgery, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuannanli Road, , Beijing 100021, Chaoyang District, P. R. China
[Abstract]
Introduction
Hepatocellular adenomas (HCAs), with a risk of malignant transformation into hepatocellular carcinoma (HCC), classically develop in young women who are taking oral contraceptives. It is now clear that HCAs may also occur in men. However, it is rarely reported that HCAs with malignant transformation occur in male patients with non-cirrhotic livers. This study aimed to characterize the malignancy of HCAs occurring in male patients.
Methods
All patients with HCAs with malignant transformation who underwent hepatectomy at the Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College between January 1, 1999 and December 31, 2011 were enrolled in the study. The clinical characteristics as well as radiologic and pathologic data were reviewed.
Results
HCAs with malignant transformation were observed in 5 male patients with non-cirrhotic livers, but not in female patients. The alpha-fetoprotein (AFP) levels were higher in patients with HCAs with malignant transformation than in patients with HCAs without malignant transformation. The diameters of the tumors with malignant transformation were larger than 5 cm in 3 cases and smaller than 5 cm in 2 cases. The 5 patients were all alive without recurrence by the end of the study period. The disease-free survival times of the 5 patients were 26, 48, 69, 69, and 92 months.
Conclusion
Our results indicate that resection would be advised even if the presumptive diagnosis is adenoma smaller than 5 cm in diameter, especially in male patients.
Introduction
Hepatocellular adenomas (HCAs), with a risk of malignant transformation into hepatocellular carcinoma (HCC), classically develop in young women who are taking oral contraceptives. It is now clear that HCAs may also occur in men. However, it is rarely reported that HCAs with malignant transformation occur in male patients with non-cirrhotic livers. This study aimed to characterize the malignancy of HCAs occurring in male patients.
Methods
All patients with HCAs with malignant transformation who underwent hepatectomy at the Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College between January 1, 1999 and December 31, 2011 were enrolled in the study. The clinical characteristics as well as radiologic and pathologic data were reviewed.
Results
HCAs with malignant transformation were observed in 5 male patients with non-cirrhotic livers, but not in female patients. The alpha-fetoprotein (AFP) levels were higher in patients with HCAs with malignant transformation than in patients with HCAs without malignant transformation. The diameters of the tumors with malignant transformation were larger than 5 cm in 3 cases and smaller than 5 cm in 2 cases. The 5 patients were all alive without recurrence by the end of the study period. The disease-free survival times of the 5 patients were 26, 48, 69, 69, and 92 months.
Conclusion
Our results indicate that resection would be advised even if the presumptive diagnosis is adenoma smaller than 5 cm in diameter, especially in male patients.
Chinese Journal of Cancer 2015, Volume: 34, Issue 5
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Song-Lin An, Li-Ming Wang, Wei-Qi Rong, Fan Wu, Wei Sun, Wei-Bo Yu, Li Feng, Fa-Qiang Liu, Fei Tian and Jian-Xiong Wu. Hepatocellular adenoma with malignant transformation in male patients with non-cirrhotic livers. Chin J Cancer. 2015, 34:17. doi:10.1186/s40880-015-0014-x
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[ Html full-text / Citation export] (BioMed Central)
[Google Scholar]
[ More articles of the special series on Hepatocellular Carcinoma ]
Cite this article
Song-Lin An, Li-Ming Wang, Wei-Qi Rong, Fan Wu, Wei Sun, Wei-Bo Yu, Li Feng, Fa-Qiang Liu, Fei Tian and Jian-Xiong Wu. Hepatocellular adenoma with malignant transformation in male patients with non-cirrhotic livers. Chin J Cancer. 2015, 34:17. doi:10.1186/s40880-015-0014-x
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