doi: 10.1186/s40880-015-0030-x

Anti-tumor activities and apoptotic mechanism of ribosome-inactivating proteins

Meiqi Zeng, Manyin Zheng, Desheng Lu, Jun Wang, Wenqi Jiang and Ou Sha

School of Medicine, Shenzhen University Health Science Center, Shenzhen 518060, Guangdong, People’s Republic of China

[Abstract] Ribosome-inactivating proteins (RIPs) belong to a family of enzymes that attack eukaryotic ribosomes and potently inhibit cellular protein synthesis. RIPs possess several biomedical properties, including anti-viral and anti-tumor activities. Multiple RIPs are known to inhibit tumor cell proliferation through inducing apoptosis in a variety of cancers, such as breast cancer, leukemia/lymphoma, and hepatoma. This review focuses on the anti-tumor activities of RIPs and their apoptotic effects through three closely related pathways: mitochondrial, death receptor, and endoplasmic reticulum pathways.

Chinese Journal of Cancer 2015, Volume: 34, Issue 8

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Meiqi Zeng, Manyin Zheng, Desheng Lu, Jun Wang, Wenqi Jiang and Ou Sha. Anti-tumor activities and apoptotic mechanism of ribosome-inactivating proteins. Chin J Cancer. 2015, 34:30. doi:10.1186/s40880-015-0030-x


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