doi: 10.5732/cjc.013.10114

Targeted therapy: tailoring cancer treatment

Min Yan, Quentin Qiang Liu

State Key Laboratory of Oncology in South China; Research Department, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P. R. China

[Abstract] Targeted therapies include small-molecule inhibitors and monoclonal antibodies, have made treatment more tumor-specific and less toxic, and have opened new possibilities for tailoring cancer treatment. Nevertheless, there remain several challenges to targeted therapies, including molecular identification, drug resistance, and exploring reliable biomarkers. Here, we present several selected signaling pathways and molecular targets involved in human cancers including Aurora kinases, PI3K/mTOR signaling, FOXO-FOXM1 axis, and MDM2/MDM4-p53 interaction. Understanding the molecular mechanisms for tumorigenesis and development of drug resistance will provide new insights into drug discovery and design of therapeutic strategies for targeted therapies.

Chinese Journal of Cancer 2013, Volume: 32, Issue 7, Page: 363-364

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Min Yan, Quentin Qiang Liu. Targeted therapy: tailoring cancer treatment . Chin J Cancer. 2013, 32(7):363-364. doi:10.5732/cjc.013.10114


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