doi: 10.5732/cjc.012.10198
Germinal-center type B-cell classification and clinical characteristics of Chinese pediatric diffuse large B-cell lymphoma: a report of 76 cases
Yan Chen, Xiao-Fei Sun, Zi-Jun Zhen, Juan Wang, Jia Zhu, Su-Ying Lu, Fei-Fei Sun, Fei Zhang, Peng-Fei Li, Rui-Qing Cai
State Key Laboratory of Oncology in South China, Department of Pediatric Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P. R. China.
[Abstract] Pediatric diffuse large B-cell lymphoma (DLBCL) is a highly aggressive disease with unique clinical characteristics. This study analyzed the germinal-center type B-cell (GCB) classification and clinical characteristics of Chinese pediatric DLBCL. A total of 76 patients with DLBCL newly diagnosed in Sun Yat-sen University Cancer Center between February 2000 and May 2011, with an age younger than 18 years, were included in the analysis. The male/female ratio was 3.47:1. The median age was 12 years (range, 2 to 18 years), and 47 (61.8%) patients were at least 10 years old. Of the 76 patients, 48 (63.2%) had stage III/IV disease, 9 (11.8%) had bone marrow involvement, 1 (1.3%) had central nervous system (CNS) involvement, and 5 (6.6%) had bone involvement. The GCB classification was assessed in 45 patients: 26 (57.8%) were classified as GCB subtype, and 19 (42.2%) were classified as non-GCB subtype. The modified B-NHL-BFM-90/95 regimen was administered to 50 patients, and the 4-year event-free survival (EFS) rate was 85.8%. Among these 50 patients, 31 were assessed for the GCB classification: 17 (54.8%) were classified as GCB subtype, with a 4-year EFS rate of 88.2%; 14 (45.2%) were classified as non-GCB subtype, with a 4-year EFS rate of 92.9%. Our data indicate that bone marrow involvement and stage III/IV disease are common in Chinese pediatric DLBCL patients, whereas the percentage of patients with the GCB subtype is similar to that of patients with the non-GCB subtype. The modified B-NHL-BFM-90/95 protocol is an active and effective treatment protocol for Chinese pediatric patients with DLBCL.
Chinese Journal of Cancer 2013, Volume: 32, Issue 10, Page: 561-566
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Yan Chen, Xiao-Fei Sun, Zi-Jun Zhen, Juan Wang, Jia Zhu, Su-Ying Lu, Fei-Fei Sun, Fei Zhang, Peng-Fei Li, Rui-Qing Cai. Germinal-center type B-cell classification and clinical characteristics of Chinese pediatric diffuse large B-cell lymphoma: a report of 76 cases. Chin J Cancer. 2013, 32(10):561-566. doi:10.5732/cjc.012.10198
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[ Html full-text ](PubMed Central)
[ PubMed ]
[Google Scholar]
Cite this article
Yan Chen, Xiao-Fei Sun, Zi-Jun Zhen, Juan Wang, Jia Zhu, Su-Ying Lu, Fei-Fei Sun, Fei Zhang, Peng-Fei Li, Rui-Qing Cai. Germinal-center type B-cell classification and clinical characteristics of Chinese pediatric diffuse large B-cell lymphoma: a report of 76 cases. Chin J Cancer. 2013, 32(10):561-566. doi:10.5732/cjc.012.10198
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