doi: 10.5732/cjc.012.10121

The absence of the ERBB4 hotspot mutations in melanomas in patients from southern China

Qi-Ming Zhou, Wei Li, Yuan-Xiang Guan, Xing Zhang, Xin-Chun Chen, Ya Ding, Xi-Zhi Wen, Rui-Qing Peng, Shu-Mei Yan, Xiao-Shi Zhang

State Key Laboratory of Oncology in South China, Guangzhou; Melanoma Unit & Biotherapy Center, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P. R. China

[Abstract] V-erb-a erythroblastic leukemia viral oncogene homolog 4 (ERBB4) has been reported to be somatically mutated in 19% of melanoma cases. To investigate the prevalence of ERBB4 mutations in melanoma patients from southern China, we analyzed 117 formalin-fixed, paraffin-embedded melanoma samples archived in the Sun Yat-sen University Cancer Center. A matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) platform was used to screen for mutations. No ERBB4 hotspot mutations were detected. Our results indicate that ERBB4 mutations may play a limited role in melanomas in China; therefore, targeting the ERBB4 mutation in melanoma patients from southern China may not be a promising strategy.

Chinese Journal of Cancer 2013, Volume: 32, Issue 7, Page: 410-414

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Qi-Ming Zhou, Wei Li, Yuan-Xiang Guan, Xing Zhang, Xin-Chun Chen, Ya Ding, Xi-Zhi Wen, Rui-Qing Peng, Shu-Mei Yan, Xiao-Shi Zhang. The absence of the ERBB4 hotspot mutations in melanomas in patients from southern China . Chin J Cancer. 2013, 32(7):410-414. doi:10.5732/cjc.012.10121


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