doi: 10.5732/cjc.012.10087
Strategies for targeting the DNA damage response for cancer therapeutics
Dan Zhang, Hai-Bo Wang, Kathryn L. Brinkman, Su-Xia Han, Bo Xu
Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiaotong University Medical School, Xi'an, Shaanxi 710061, P. R. China
[Abstract] The DNA damage response is critical for cells to maintain genome stability and survival. In this review, we discuss approaches to targeting critical elements of the DNA damage response for radiosensitization and chemosensitization. In addition, we also discuss strategies for targeting DNA damage response and DNA repair defects in cancer cells for synthetic lethality.
Chinese Journal of Cancer 2012, Volume: 31, Issue 8, Page: 359-363
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Dan Zhang, Hai-Bo Wang, Kathryn L. Brinkman, Su-Xia Han, Bo Xu. Strategies for targeting the DNA damage response for cancer therapeutics. Chin J Cancer. 2012, 31(8):359-363. doi:10.5732/cjc.012.10087
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[ Html full-text ](PubMed Central)
[ PubMed ]
[Google Scholar]
Cite this article
Dan Zhang, Hai-Bo Wang, Kathryn L. Brinkman, Su-Xia Han, Bo Xu. Strategies for targeting the DNA damage response for cancer therapeutics. Chin J Cancer. 2012, 31(8):359-363. doi:10.5732/cjc.012.10087
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