doi: 10.5732/cjc.012.10041

Individualized leukemia cell-population profiles in common B-cell acute lymphoblastic leukemia patients

Jian-Hua Yu, Jing-Tao Dong, Yong-Qian Jia, Neng-Gang Jiang, Ting-Ting Zeng, Hong Xu , Xian-Ming Mo , Wen-Tong Meng

Department of Laboratory Medicine, Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China.

[Abstract] Immunophenotype is critical for diagnosing common B-cell acute lymphoblastic leukemia (common ALL) and detecting minimal residual disease. We developed a protocol to explore the immunophenotypic profiles of common ALL based on the expression levels of the antigens associated with B lymphoid development, including IL-7Rα (CD127), cytoplasmic CD79a (cCD79a), CD19, VpreB (CD179a), and sIgM, which are successive and essential for progression of B cells along their developmental pathway. Analysis of the immunophenotypes of 48 common ALL cases showed that the immunophenotypic patterns were highly heterogeneous, with the leukemic cell population differing from case to case. Through the comprehensive analysis of immunophenotypic patterns, the profiles of patient-specific composite leukemia cell populations could provide detailed information helpful for the diagnosis, therapeutic monitoring, and individualized therapies for common ALL.

Chinese Journal of Cancer 2013, Volume: 32, Issue 4, Page: 213-223

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Jian-Hua Yu, Jing-Tao Dong, Yong-Qian Jia, Neng-Gang Jiang, Ting-Ting Zeng, Hong Xu , Xian-Ming Mo , Wen-Tong Meng. Individualized leukemia cell-population profiles in common B-cell acute lymphoblastic leukemia patients. Chin J Cancer. 2013, 32(4):213-223. doi:10.5732/cjc.012.10041


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