doi: 10.5732/cjc.011.10420

R-CHOP regimen can significantly decrease the risk of disease relapse and progression in patients with non-germinal center B-cell subtype diffuse large B-cell lymphoma

Xiao-Hui He, Bo Li, Sheng Yang, Ning Lu, Xun Zhang, Shuang-Mei Zou, Ye-Xiong Li, Yong-Wen Song, Shan Zheng, Mei Dong, Sheng-Yu Zhou, Jian-Liang Yang, Peng Liu, Chang-Gong Zhang, Yan Qin, Feng-Yi Feng, Yuan-Kai Shi

Department of Medical Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P. R. China.

[Abstract] To further explore the role of rituximab when added to the CHOP-like regimen in the treatment of immunohistochemically defined non-germinal center B-cell subtype (non-GCB) diffuse large B-cell lymphoma(DLBCL), 159 newly diagnosed DLBCL patients were studied retrospectively based on the immunohistochemical evaluation of CD10, Bcl-6, MUM-1, and Bcl-2. Altogether, 110 patients underwent the CHOP-like regimen, and rituximab was added for the other 49 patients. Cox regression analysis showed that compared with the CHOP-like regimen, the rituximab-based regimen(R-CHOP regimen) significantly decreased the risk of disease relapse and progression in CD10-negative patients (P = 0.001), Bcl-6-negative patients (P = 0.01), and MUM-1-positive patients (P = 0.003). The risk of disease relapse in patients with non-GCB subtype(P = 0.002) also decreased. In contrast, patients with the opposite immunohistochemical marker expression profile and GCB subtype did not benefit from treatment with the R-CHOP regimen. In addition, non-GCB subtype patients had a significantly higher expression rate of Bcl-2 than GCB subtype patients (P = 0.042). Although univariate analysis found that both Bcl-2-positive and -negative patients had significantly higher event-free survival rates with the R-CHOP regimen, only Bcl-2 positivity(P = 0.004) maintained significance in the Cox regression analysis. We conclude that the addition of rituximab can significantly improve the prognosis of patients with non-GCB subtype DLBCL, which is closely related to the expression of CD10, Bcl-6, MUM-1, and Bcl-2.

Chinese Journal of Cancer 2012, Volume: 31, Issue 6, Page: 306-314

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Xiao-Hui He, Bo Li, Sheng Yang, Ning Lu, Xun Zhang, Shuang-Mei Zou, Ye-Xiong Li, Yong-Wen Song, Shan Zheng, Mei Dong, Sheng-Yu Zhou, Jian-Liang Yang, Peng Liu, Chang-Gong Zhang, Yan Qin, Feng-Yi Feng, Yuan-Kai Shi. R-CHOP regimen can significantly decrease the risk of disease relapse and progression in patients with non-germinal center B-cell subtype diffuse large B-cell lymphoma. Chin J Cancer. 2012, 31(6):306-314. doi:10.5732/cjc.011.10420


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