doi: 10.5732/cjc.011.10367

Application of mesenchymal stem cells as a vehicle to deliver replication-competent adenovirus for treating malignant glioma

Cui Hai, Yong-Min Jin, Wen-Biao Jin, Zhe-Zhu Han, Mei-Nv Cui, Xue-Zhe Piao, Xiong-Hu Shen, Song-Nan Zhang, Hong-Hua Sun

Department of Oncology, Affiliated Hospital of Yanbian University, Yanji, Jilin 133000, P.R. China

[Abstract] Although gene therapy was regarded as a promising approach for glioma treatment, its therapeutic efficacy was often disappointing because of the lack of efficient drug delivery systems. Mesenchymal stem cells(MSCs) have been reported to have a tropism for brain tumors and thus could be used as delivery vehicles for glioma therapy. Therefore, in this study, we attempted to treat glioma by using MSCs as a vehicle for delivering replication-competent adenovirus. We firstly compared the infectivity of type 3, type 5, and type 35 fiber-modified adenoviruses in MSCs. We also determined suitable adenovirus titer in vitro and then used this titer to analyze the ability of MSCs to deliver replication-competent adenovirus into glioma in vivo. Our results indicated that type 35 fiber-modified adenovirus showed higher infectivity than did naked type 3 or type 5 fiber-modified adenovirus. MSCs carrying replication-competent adenovirus significantly inhibited tumor growth in vivo compared with other control groups. In conclusion, MSCs are an effective vehicle that can successfully transport replication-competent adenovirus into glioma, making it a potential therapeutic strategy for treating malignant glioma.

Chinese Journal of Cancer 2012, Volume: 31, Issue 5, Page: 233-240

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Cui Hai, Yong-Min Jin, Wen-Biao Jin, Zhe-Zhu Han, Mei-Nv Cui, Xue-Zhe Piao, Xiong-Hu Shen, Song-Nan Zhang, Hong-Hua Sun. Application of mesenchymal stem cells as a vehicle to deliver replication-competent adenovirus for treating malignant glioma. Chin J Cancer. 2012, 31(5):233-240. doi:10.5732/cjc.011.10367


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