doi: 10.5732/cjc.011.10175

Recent progress in the study of methylated tumor suppressor genes in gastric cancer

Xiao-Tong Hu, Chao He

Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province， Sir Run Run Shaw Hospital, Hangzhou, Zhejiang 310016, P. R. China

[Abstract] Gastric cancer is one of the most common malignancies and a leading cause of cancer mortality worldwide. The pathogenesis mechanisms of gastric cancer are still not fully clear. Inactivation of tumor suppressor genes and activation of oncogenes caused by genetic and epigenetic alterations are known to play significant roles in carcinogenesis. Accumulating evidence has shown that epigenetic silencing of the tumor suppressor genes, particularly caused by hypermethylation of CpG islands in promoters, is critical to carcinogenesis and metastasis. Here, we review the recent progress in the study of methylations of tumor suppressor genes involved in the pathogenesis of gastric cancer. We also briefly describe the mechanisms that induce tumor suppressor gene methylation and the status of translating these molecular mechanisms into clinical applications.

Chinese Journal of Cancer 2013, Volume: 32, Issue 1, Page: 31-41

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Xiao-Tong Hu, Chao He. Recent progress in the study of methylated tumor suppressor genes in gastric cancer. Chin J Cancer. 2013, 32(1):31-41. doi:10.5732/cjc.011.10175


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