doi: 10.5732/cjc.011.10070

Association between single nucleotide polymorphisms on chromosome 17q and the risk of prostate cancer in a Chinese population

Chang-Hu Zhou, Jian-Ye Wang, Su-Yan Cao, Xiao-Hong Shi, Yao-Guang Zhang, Ming Liu, Xin Wang, Jin Huang, Yi-Ge Yang, Dong Wei, Ze Yang

The Fifth School of Clinical Medicine, Peking University, Beijing 100730, P. R. China. caosuyan.happy@163.com.

[Abstract] In European populations, 7 single nucleotide polymorphisms (SNPs) on chromosome 17q, 3 SNPs on 17q12, and 4 SNPs on 17q24.3 were recently identified to be closely related to the risk of prostate cancer by a genome-wide association study. In Japanese populations, the correlation between 2 SNPs on 17q and the risk of prostate cancer and tumor aggressiveness was also confirmed by a large-scale experiment. However, whether 17q is associated with prostate cancer and its clinical manifestations in Chinese populations is still unknown. Therefore, we conducted a case-control study in a northern Chinese population and tested 2 SNPs, rs4430796 and rs1859962, on 17q in 124 prostate cancer patients and 111 controls using polymerase chain reaction-high resolution melting curve (PCR-HRM) combined with sequencing. We analyzed the association of the 2 SNPs with the risk of prostate cancer as well as patients’ lifestyles, onset ages, Gleason scores, PSA levels, and pathologic stages. We found a significant difference in the G allele of SNP rs1859962 (P = 0.035, OR = 1.51, 95% CI = 1.03-2.21) but not in the rs4430796 genotype frequency or allele frequency distribution between prostate cancer patients and the controls (P > 0.05). Neither of the SNPs was significantly associated with the onset age, Gleason score, PSA level, pathologic stage, or other clinical indicators of patients with prostate cancer (P > 0.05). Our results show that polymorphism of the G allele of SNP rs1859962 is associated with the risk of prostate cancer in a Chinese population.

Chinese Journal of Cancer 2011, Volume: 30, Issue 10, Page: 721-730

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Chang-Hu Zhou, Jian-Ye Wang, Su-Yan Cao, Xiao-Hong Shi, Yao-Guang Zhang, Ming Liu, Xin Wang, Jin Huang, Yi-Ge Yang, Dong Wei, Ze Yang. Association between single nucleotide polymorphisms on chromosome 17q and the risk of prostate cancer in a Chinese population. Chin J Cancer. 2011, 30(10):721-730. doi:10.5732/cjc.011.10070


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