doi: 10.5732/cjc.011.10059
Lung carcinoma signaling pathways activated by smoking
Jing Wen, Jian-Hua Fu, Wei Zhang, Ming Guo
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030-4009, USA.mguo@mdanderson.org
[Abstract] Lung cancer is the leading cause of cancer death in men and women worldwide, with over a million deaths annually. Tobacco smoke is the major etiologic risk factor for lung cancer in current or previous smokers and has been strongly related to certain types of lung cancer, such as small cell lung carcinoma and squamous cell lung carcinoma. In recent years, there has been an increased incidence of lung adenocarcinoma. This change is strongly associated with changes in smoking behavior and cigarette design. Carcinogens present in tobacco products and their intermediate metabolites can activate multiple signaling pathways that contribute to lung cancer carcinogenesis. In this review, we summarize the smoking-activated signaling pathways involved in lung cancer.
Chinese Journal of Cancer 2011, Volume: 30, Issue 8, Page: 551-558
[ PDF Full-text ]
[Google Scholar]
Cite this article
Jing Wen, Jian-Hua Fu, Wei Zhang, Ming Guo. Lung carcinoma signaling pathways activated by smoking. Chin J Cancer. 2011, 30(8):551-558. doi:10.5732/cjc.011.10059
Export citations
EndNote
[Google Scholar]
Cite this article
Jing Wen, Jian-Hua Fu, Wei Zhang, Ming Guo. Lung carcinoma signaling pathways activated by smoking. Chin J Cancer. 2011, 30(8):551-558. doi:10.5732/cjc.011.10059
Export citations
EndNote
SHARE THIS ARTICLE
Comments: