doi: 10.5732/cjc.011.10055
MLL1/WDR5 complex in leukemogenesis and epigenetic regulation
Min Wu and Hong-Bing Shu
College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, P. R. China. wumin@whu.edu.cn.
[Abstract] MLL1 is a histone H3Lys4 methyltransferase and forms a complex with WDR5 and other components. It plays important roles in developmental events, transcriptional regulation, and leukemogenesis. MLL1-fusion proteins resulting from chromosomal translocations are molecular hallmarks of a special type of leukemia, which occurs in over 70% infant leukemia patients and often accompanies poor prognosis. Investigations in the past years on leukemogenesis and the MLL1-WDR5 histone H3Lys4 methyltransferase complex demonstrate that epigenetic regulation is one of the key steps in development and human diseases.
Chinese Journal of Cancer 2011, Volume: 30, Issue 4, Page: 240-246
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Min Wu and Hong-Bing Shu. MLL1/WDR5 complex in leukemogenesis and epigenetic regulation. Chin J Cancer. 2011, 30(4):240-246. doi:10.5732/cjc.011.10055
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Min Wu and Hong-Bing Shu. MLL1/WDR5 complex in leukemogenesis and epigenetic regulation. Chin J Cancer. 2011, 30(4):240-246. doi:10.5732/cjc.011.10055
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