doi: 10.5732/cjc.011.10041

Mouse models of colorectal cancer

Yunguang Tong, Wancai Yang, H. Phillip Koeffler

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. tongy@cshs.org.

[Abstract] Colorectal cancer is one of the most common malignancies in the world. Many mouse models have been developed to evaluate features of colorectal cancer in humans. These can be grouped into genetically-engineered, chemically-induced, and inoculated models. However, none recapitulates all of the characteristics of human colorectal cancer. It is critical to use a specific mouse model to address a particular research question. Here, we review commonly used mouse models for human colorectal cancer.

Chinese Journal of Cancer 2011, Volume: 30, Issue 7, Page: 450-462

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Yunguang Tong, Wancai Yang, H. Phillip Koeffler. Mouse models of colorectal cancer. Chin J Cancer. 2011, 30(7):450-462. doi:10.5732/cjc.011.10041


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