doi: 10.5732/cjc.010.10592

A single nucleotide polymorphism in the matrix metalloproteinase 2 promoter is closely associated with high risk of nasopharyngeal carcinoma in Cantonese from southern China

Jian-Yong Shao, Yun Cao, Xiao-Ping Miao, Ma-Yan Huang, Ling Deng, Jian-Jun Hao, Xiao-Man Liang, Li-Fu Hu, Ingemar Ernberg, Dong-Xin Lin Yi-Xin Zeng

State Key Laboratory of Oncology in South China; Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P. R. China. shaojy@sysucc.org.cn

[Abstract] Matrix metalloproteinase 2 (MMP2) has been shown to play an important role in several steps of cancer development. The -1306C/T polymorphism of the MMP2 gene displays a strikingly lower promoter activity than the T allele, and the CC genotype in the MMP2 promoter has been reported to associate with the development of several cancers. To assess the contribution of the MMP2 -1306C/T polymorphism to the risk of nasopharyngeal carcinoma (NPC), we conducted a case-control study and analyzed MMP2 genotypes in 370 patients with NPC and 390 frequency-matched controls using real-time PCR-based TaqMan allele analysis. We found that subjects with the CC genotype had an increased risk (OR = 1.55, 95% CI = 1.05-2.27) of developing NPC compared to those with the CT or TT genotypes. Furthermore, we found that the risk of NPC was markedly increased in subjects who were smokers (OR = 15.04, 95% CI = 6.65-33.99), heavy smokers who smoked ⩾20 pack-years (OR = 18.66, 95% CI = 7.67-45.38), or young (<60 years) at diagnosis (OR = 1.52, 95% CI = 1.01-2.29). Our results provide molecular epidemiological evidence that the MMP2 -1306C/T promoter polymorphism is associated with NPC risk, and this association is especially noteworthy in heavy smokers.

Chinese Journal of Cancer 2011, Volume: 30, Issue 9, Page: 620-626

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Jian-Yong Shao, Yun Cao, Xiao-Ping Miao, Ma-Yan Huang, Ling Deng, Jian-Jun Hao, Xiao-Man Liang, Li-Fu Hu, Ingemar Ernberg, Dong-Xin Lin Yi-Xin Zeng. A single nucleotide polymorphism in the matrix metalloproteinase 2 promoter is closely associated with high risk of nasopharyngeal carcinoma in Cantonese from southern China. Chin J Cancer. 2011, 30(9):620-626. doi:10.5732/cjc.010.10592


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