doi: 10.5732/cjc.010.10402

Radiotherapy of unicentric mediastinal Castleman’s disease

Yue-Min Li, Peng-Hui Liu, Yu-Hai Zhang, Huo-Sheng Xia, Liang-Liang Li, Yi-Mei Qu, Yong Wu, Shou-Yun Han, Guo-Qing Liao and Yong-Dong Pu

Cancer Center, PLA 309 Hospital, Beijing 100091, P.R. China.yongdongpu@yahoo.com.cn.

[Abstract] Castleman’s disease is a slowly progressive and rare lymphoproliferative disorder. Here, we report a 55-year-old woman with superior mediastinal Castleman’s disease being misdiagnosed for a long term. We found a 4.3 cm mass localized in the superior mediastinum accompanied with severe clinical symptoms. The patient underwent an exploratory laparotomy, but the mass failed to be totally excised. Pathologic examination revealed a mediastinal mass of Castleman’s disease. After radiotherapy of 30 Gy by 15 fractions, the patient no longer presented previous symptoms. At 3 months after radiotherapy of 60 Gy by 30 fractions, Computed tomography of the chest showed significantly smaller mass, indicating partial remission. Upon a 10-month follow-up, the patient was alive and free of symptoms.

Chinese Journal of Cancer 2011, Volume: 30, Issue 5, Page: 351-356

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Yue-Min Li, Peng-Hui Liu, Yu-Hai Zhang, Huo-Sheng Xia, Liang-Liang Li, Yi-Mei Qu, Yong Wu, Shou-Yun Han, Guo-Qing Liao and Yong-Dong Pu. Radiotherapy of unicentric mediastinal Castleman’s disease. Chin J Cancer. 2011, 30(5):351-356. doi:10.5732/cjc.010.10402


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