doi: 10.5732/cjc.010.10302

Nasal metastases from renal cell carcinoma are associated with Memorial Sloan-Kettering Cancer Center poor-prognosis classification

Caroline Victoria Choong, Tiffany Tang, Wen Yee Chay, Christopher Goh, Miah Hiang Tay, Nor Azhari Mohd Zam, Puay Hoon Tan, Min-Han Tan

Department of Medical Oncology, National Cancer Centre, Singapore, Singapore 169610, Republic of Singapore. tan.min.han@nccs.com.sg

[Abstract] Unusual sites of metastases are recognized in patients with renal cell carcinoma (RCC). However, the prognostic implications of these sites are not well understood. We used the Memorial Sloan-Kettering Cancer Center (MSKCC) risk classification for metastatic RCC to evaluate 912 consecutive patients with RCC managed at the Singapore General Hospital between 1990 and 2009. Among these patients, 301 had metastases either at diagnosis or during the course of illness. Nasal metastases, all arising from clear cell RCC, were identified histologically in 4 patients (1.3% of those with metastasis). All 4 patients were classified as MSKCC poor prognosis by current risk criteria. Nasal metastases were significantly associated with lung and bone metastases. The frequency of nasal metastases in patients with metastatic RCC is about 1%, occurring predominantly in patients with clear cell RCC. Nasal metastases are associated with poor prognosis as estimated by the MSKCC risk classification, with attendant implications for selection of targeted therapy, and are usually associated with multi-organ dissemination, including concurrent lung and bone involvement.

Chinese Journal of Cancer 2011, Volume: 30, Issue 2, Page: 144-148

[ PDF Full-text ]
[Google Scholar]

Cite this article

Caroline Victoria Choong, Tiffany Tang, Wen Yee Chay, Christopher Goh, Miah Hiang Tay, Nor Azhari Mohd Zam, Puay Hoon Tan, Min-Han Tan. Nasal metastases from renal cell carcinoma are associated with Memorial Sloan-Kettering Cancer Center poor-prognosis classification. Chin J Cancer. 2011, 30(2):144-148. doi:10.5732/cjc.010.10302


Export citations

EndNote