doi: 10.5732/cjc.010.10162

Protein folding, protein homeostasis, and cancer

John H. Van Drie

Van Drie Research, Andover, MA 01810, USA. john@vandrieresearch.com

[Abstract] Proteins fold into their functional 3-dimensional structures from a linear amino acid sequence. In vitro this process is spontaneous; while in vivo it is orchestrated by a specialized set of proteins, called chaperones. Protein folding is an ongoing cellular process, as cellular proteins constantly undergo synthesis and degradation. Here emerging links between this process and cancer are reviewed. This perspective both yields insights into the current struggle to develop novel cancer chemotherapeutics and has implications for future chemotherapy discovery.

Chinese Journal of Cancer 2011, Volume: 30, Issue 2, Page: 124-137

[ PDF Full-text ]
[Google Scholar]

Cite this article

John H. Van Drie. Protein folding, protein homeostasis, and cancer. Chin J Cancer. 2011, 30(2):124-137. doi:10.5732/cjc.010.10162


Export citations

EndNote