Chinese Journal of Cancerindexed by SCI

Expressions of osteopontin and B7-H4 in epithelial ovarian neoplasm and their significance
Li-Li Zhang, Shu-Li Shao, Yan Wu
The Second Clinical Hospital of Shanxi Medical University,Taiyuan, 030001, Shanxi, P. R. China.
[Abstract] Background and Objective: Epithelial ovarian cancer involved a number of factors. Recent studies have shown that osteopontin (OPN) was related to carcinogenesis and development of a variety of tumors, but few studies on ovarian cancer were reported. B7-H4 is a newly identified tumor marker in ovarian cancer. This study was to explore the expressions of OPN and B7-H4 and their clinical significance in epithelial ovarian tumors. Methods: The expressions of OPN and B7-H4 in 15 cases of normal ovarian tissue, 20 benign ovarian tumor tissue, 20 borderline ovarian tumor tissue, and 40 ovarian cancer tissue were detected by immunohistochemistry, and the relationship of the expressions of OPN and B7-H4 to clinical and pathologic features of ovarian cancer was analyzed. Results: The expressions of OPN and B7-H4 were higher in the ovarian cancer than in the borderline ovarian tumor and the benign tumor, and the difference was significant (P<0.05). The positive rates of OPN and B7-H4 were significantly higher in the poorly-differentiated ovarian cancer than in the moderately-and well-differentiated ovarian cancer (P<0.05), and the expressions were significantly lower in Stages I and II of ovarian cancer tissues than in Stages III and IV (P<0.05). The positive rate of OPN was statistically associated with lymph node metastasis (P <0.05) but not with age or histologic type. The positive rate of B7-H4 were significantly higher in the ovarian serous carcinoma than in the mucous carcinoma (P<0.05), but was not statistically related to age and lymph node metastasis. Conclusion: The expressions of OPN and B7-H4 increased in epithelial ovarian cancer, which could provide a reference for the diagnosis of ovarian malignant tumor.
Chinese Journal of Cancer 2010, Volume: 29, Issue 1, Page: 24-
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