Cancer Communications
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Volume:36 Issue:11   2017

The programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) pathway is important in the negative regulation of cell-mediated immune responses. Immunotherapy targeting the PD-1/PD-L1 axis has great promise in treating many types of cancer and was a breakthrough in cancer treatment. The cover art shows that the intensity of PD-1 expression on CD8(+) T cells in primary tumors and in metastatic lymph nodes were stronger than that in tumor-free lymph nodes from the same patient. For more details, please read the article on pages 560-573 of this CJC issue. (The cover art is provided by Dr. Yuan Gao and colleagues.)

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