Cancer Communications
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Volume:36 Issue:7   2017

Metformin (1,1-dimethylbiguanide hydrochloride), an inexpensive and well-tolerated oral agent commonly used in the first-line treatment of type 2 diabetes, has become the focus of intense research as a candidate anticancer agent. Metformin can be used as a sensitizer or be combined with conventional chemotherapeutic agents and radiotherapy to combat cancer. Metformin plays an important role in targeting cancer stem cells (CSCs) and reversing the epithelial-mesenchymal transition (EMT), a critical process in cancer metastasis. The cover art shows the possible signaling pathways involved in the anticancer effects of metformin. For more details, please read the paper on pages 289-297 of the present CJC issue. (The original cover art is provided by Yi Lu and colleagues.)

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