Cancer Communications
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Volume:36 Issue:5   2017

The mortality and incidence of acute myeloid leukemia are associated with multiple factors. Distinct genetic and chromosomal aberrations differentially affect the phenotype and prognosis of individuals with leukemia. The t(8;21)(q22;q22) translocation, which is observed in patients with acute myeloid leukemia with maturation, is characterized by the fusion of AML1 (acute myeloid leukemia factor 1) on chromosome 21 and ETO (eight-twenty-one) on chromosome 8. The cover art shows the three-dimensional reconstruction of nuclei, which are stained blue. Red signals indicate either chromosome 21 or 18, and green signals indicate chromosome 8. For more details, please read the paper on pages 241-244 of the present CJC issue. (The cover art is provided by Wanyun Ma and colleagues.)

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