Cancer Communications
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Volume:36 Issue:1   2017

Ankyrin repeat and SOCS box protein 3 (ASB3) is a member of ASB family and contains ankyrin repeat sequence and SOCS box domain. Previous studies indicated that it mediates the ubiquitination and degradation of tumor necrosis factor receptor 2 and is likely involved in inflammatory responses. The present study of the cover art found that ASB3 dysfunction resulted from gene mutations or down-regulated expression frequently exists in colorectal cancer (CRC) and likely plays a key role in the pathogenesis and progression of CRC. The cover art show comparison among three-dimensional (3D) models of wild type (WT) ASB3 and ASB3 mutant proteins by computer homogeneity modeling and prediction with the SWISS-MODEL. a, Images of spatial of structure of ASB3 from two different angles. b, Image of 3D model of G135E (ASB3G135E, on the left). c, Image of 3D model of K339I (ASB3K339I, on the right). d, Images of spatial structure of G135E/K339I (ASB3G135EK339I) from two different angles. e, Structure sketch of ASB3 protein with G135E and K339I mutations. For more details, please read the paper on pages 11-25 of the present CJC issue. (The cover art is provided by Ran-Yi Liu, Wen-Lin Huang and colleagues.)

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