Cancer Communications
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Volume:34 Issue:10   2015

At a bird's eye view all cancers share the same set of deregulated biological processes, termed the hallmarks of cancer. Yet, at the molecular level cancers appear very different, e.g. they can have widely differing mutation landscapes. The paper by Knijnenburg et al. describes a map that connects genes via pathways to cancer hallmarks. By projecting gene mutation data from various cancer types onto this map, the authors investigate the similarities and differences between cancer types, not only on the level of genes, but also on that of pathways and hallmarks. For more details, please read the article on pages 439-449. (The original cover art is created by Allison Kudla at the Institute for Systems Biology. )




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